Photoshop Ergonomics: Wacom Pen Buttons

I find it really useful to assign the lower button to the Option-Key, and the upper button to the Space Bar.  By assigning option to the pen, it allows you to easily change the brush size with your other hand by keeping your fingers above the left and right bracket keys.  Use your thumb to swap between the lower button (option) and the upper button (space bar / hand tool) to sample pixels, and pan across your image.

- Jeremiah